Personally, I choose to avoid any substance that affects my brain (chocolate excepted, of course). Alcohol, cancer sticks, marijuana, and all the many other things that do nasty things to neurotransmitters hold no attraction, though, having worked with many people struggling with addiction, I do understand how they can grab hold of a person.
But here is something beside the health effects of these human bear traps: they are environmentally far more damaging than most other crops or industrial products. Here is an informative, well-researched article in Deutsche Welle setting out all the ways the global drug trade is destroying water sources, forests and farmlands, and poisoning everything near their production sites.
If you happen to be an occasional or serious indulger, you might consider saving money and health by divesting from this industry.